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Article

ATM germline mutations in women with familial breast cancer and a relative with haematological malignancy.

Breast cancer research and treatment - 1 Jan 2010

Paglia Laura La, Laugé Anthony, Weber Jérémie, Champ Jérôme, Cavaciuti Eve, Russo Antonio, Viovy Jean-Louis, Stoppa-Lyonnet Dominique

Abstract excerpt

Biallelic inactivation of the ATM gene causes ataxia-telangiectasia (A-T), a complex neurological disease associated with a high risk of leukaemias and lymphomas. Mothers of A-T children, obligate ATM heterozygote mutation carriers, have a breast cancer (BC) relative risk of about 3. The frequency of ATM carriers in BC women with a BC family history has been estimated to be 2.70%. To further our clinical...

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Identifiers

PMID: 19404735
DOI: 10.1007/s10549-009-0396-z

Genes

ATM
BRCA1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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