Article
Favorable prognostic significance of CEBPA mutations in patients with de novo acute myeloid leukemia: a study from the Acute Leukemia French Association (ALFA).
Blood - 15 Oct 2002
Preudhomme Claude, Sagot Christophe, Boissel Nicolas, Cayuela Jean-Michel, Tigaud Isabelle, de Botton Stéphane, Thomas Xavier, Raffoux Emmanuel, Lamandin Charlotte, Castaigne Sylvie, Fenaux Pierre, Dombret Hervé
Abstract excerpt
The transcription factor C/EBPalpha is crucial for differentiation of mature granulocytes. Recently, different CEBPA gene mutations likely to induce differentiation arrest have been described in nearly 10% of patients with acute myeloid leukemia (AML). In the present study, we retrospectively analyzed the prognostic significance of CEBPA mutations in 135 AML patients (French-American-British [FAB]-M3 excluded)....
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