Article
Mutations of CEBPA in acute myeloid leukemia FAB types M1 and M2.
Genes, chromosomes & cancer - 1 May 2003
Snaddon Jennifer, Smith Matthew L, Neat Michael, Cambal-Parrales Maxine, Dixon-McIver Amanda, Arch Rachael, Amess John A, Rohatiner Ama Z, Lister T Andrew, Fitzgibbon Jude
Abstract excerpt
CEBPA encodes the transcription factor C/EBPalpha and is specifically up-regulated during granulocytic differentiation. The gene is mutated in approximately 20% of patients with acute myeloid leukemia (AML) FAB type M2 and occurs in the absence of the t(8;21). In much the same way as specific tra...
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