Article
Surface Roughness of Titanium Orthopedic Implants Alters the Biological Phenotype of Human Mesenchymal Stromal Cells.
Tissue engineering. Part A - 1 Dec 2021
Lewallen Eric A, Trousdale William H, Thaler Roman, Yao Jie J, Xu Wei, Denbeigh Janet M, Nair Asha, Kocher Jean-Pierre, Dudakovic Amel, Berry Daniel J, Cohen Robert C, Abdel Matthew P, Lewallen David G, van Wijnen Andre J
Abstract excerpt
Metal orthopedic implants are largely biocompatible and generally achieve long-term structural fixation. However, some orthopedic implants may loosen over time even in the absence of infection. In vivo fixation failure is multifactorial, but the fundamental biological defect is cellular dysfunction at the host-implant interface. Strategies to reduce the risk of short- and long-term loosening include surface...
Topics
- Alloys
- Animals
- Humans
- Mesenchymal Stem Cells
- Osseointegration
- Phenotype
- Prostheses and Implants
- Surface Properties
- Titanium