Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Plasmodium falciparum erythrocyte invasion through glycophorin C and selection for Gerbich negativity in human populations.

Nature medicine - 1 Jan 2003

Maier Alexander G, Duraisingh Manoj T, Reeder John C, Patel Sheral S, Kazura James W, Zimmerman Peter A, Cowman Alan F

Abstract excerpt

Geographic overlap between malaria and the occurrence of mutant hemoglobin and erythrocyte surface proteins has indicated that polymorphisms in human genes have been selected by severe malaria. Deletion of exon 3 in the glycophorin C gene (called GYPCDeltaex3 here) has been found in Melanesians; this alteration changes the serologic phenotype of the Gerbich (Ge) blood group system, resulting in Ge negativity. The...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blood Group Antigens
Share to Erythrocyte Membrane

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Erythrocytes

Share to Glycophorins

Share to Malaria, Falciparum

Share to Melanesia

Share to Plasmodium falciparum

Share to Protozoan Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 12469115
DOI: 10.1038/nm807
PMCID: PMC3728825

Genes

GYPC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Plasmodium falciparum erythrocyte invasion through glycophorin C and selection for Gerbich negativity in human populations.PMID 12469115Read ↗

Glycophorin C delta(exon3) is not associated with protection against severe anaemia in Papua New Guinea.Semantic proximity Read ↗

A single-step assay for the Gerbich-negative allele of glycophorin C.Semantic proximity Read ↗

A 3.5 kb deletion in the glycophorin C gene accounts for the Gerbich-negative blood group in Melanesians.Semantic proximity Read ↗

Genetic Evidence for Erythrocyte Receptor Glycophorin B Expression Levels Defining a Dominant Plasmodium falciparum Invasion Pathway into Human ErythrocytesSemantic proximity Read ↗

The association of the glycophorin C exon 3 deletion with ovalocytosis and malaria susceptibility in the Wosera, Papua New Guinea.Semantic proximity Read ↗

Glycophorin C (Gerbich antigen blood group) and band 3 polymorphisms in two malaria holoendemic regions of Papua New Guinea.Semantic proximity Read ↗

Genetic background of the rare Yus and Gerbich blood group phenotypes: homologous regions of the GYPC gene contribute to deletion alleles.Semantic proximity Read ↗

Erythrocyte-binding antigens of Plasmodium falciparum are targets of human inhibitory antibodies and function to evade naturally acquired immunity.Semantic proximity Read ↗

Genetic diversity of Gerbich alleles in Brazilians reveals an unexpected prevalence of the GE:-2,-3,4 phenotype.Semantic proximity Read ↗

Characterization of a Plasmodium falciparum erythrocyte-binding protein paralogous to EBA-175.Semantic proximity Read ↗

Natural selection on the erythrocyte surface.Semantic proximity Read ↗

The glycophorin C N-linked glycan is a critical component of the ligand for the Plasmodium falciparum erythrocyte receptor BAEBL.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.