Article
Genetic background of the rare Yus and Gerbich blood group phenotypes: homologous regions of the GYPC gene contribute to deletion alleles.
British journal of haematology - 1 May 2017
Gourri Elise, Denomme Gregory A, Merki Yvonne, Scharberg Erwin A, Vrignaud Cedric, Frey Beat M, Peyrard Thierry, Gassner Christoph
Abstract excerpt
The GYPC gene encodes the glycophorins C and D. The two moieties express 12 known antigens of the Gerbich blood group system and functionally stabilize red blood cell membranes through their intracellular interaction with protein 4.1 and p55. Three GYPC exon deletions are responsible for the lack of the high-frequency antigens Ge2 (Yus type, exon 2 deletion), Ge2 and Ge3 (Gerbich type, exon 3 deletion), and Ge2...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.