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Genetic polymorphism and natural selection of circumsporozoite protein in Myanmar Plasmodium vivax

3 Sept 2020

Abstract excerpt

BACKGROUND: Circumsporozoite surface protein (CSP) of malaria parasites has been recognized as one of the leading vaccine candidates. Clinical trials of vaccines for vivax malaria incorporating Plasmodium vivax CSP (PvCSP) have demonstrated their effectiveness in preventing malaria, at least in part. However, genetic diversity of pvcsp in the natural population remains a major concern. METHODS: A total of 171...

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PMID: 32883283
DOI: 10.1186/s12936-020-03366-7

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