Article
Skeletal muscle of mice with a mutation in slow alpha-tropomyosin is weaker at lower lengths.
Neuromuscular disorders : NMD - 1 Dec 2002
de Haan A, van der Vliet M R, Gommans I M P, Hardeman E C, van Engelen B G M
Abstract excerpt
Skeletal muscle function was measured in anaesthetised transgenic mice having a mutation in the TPM3 gene (slow alpha-tropomyosin), a similar mutation as found in some patients with nemaline myopathy, and was compared with control muscles. Measurements of isometric and dynamic muscle performance were done with electrical nerve stimulation at physiological temperatures. No muscle weakness was found in the...
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