Article
Muscle LIM protein is upregulated in fast skeletal muscle during transition toward slower phenotypes.
American journal of physiology. Cell physiology - 1 Feb 2001
Willmann R, Kusch J, Sultan K R, Schneider A G, Pette D
Abstract excerpt
Muscle LIM protein (MLP) is constitutively expressed in slow, but undetectable in fast, muscles of the rat. Here we show that MLP was upregulated at both the mRNA and protein levels under experimental conditions leading to transitions from fast to slower phenotypes. Chronic low-frequency stimulation and mechanical overloading by synergist removal both induced fast-to-slow shifts in myosin heavy chain (MHC)...
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