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Article

Effects of aging on actin sliding speed on myosin from single skeletal muscle cells of mice, rats, and humans

1 Apr 2001

Abstract excerpt

The effects of aging on the mechanical properties of myosin were measured in 87 fibers from muscles of humans (n = 40), rats (n = 21), and mice (n = 26) using a single fiber in vitro motility assay. Irrespective of species, an 18-25% aging-related slowing in the speed of actin filaments was observed from 62 single fibers expressing the slow (type I) beta-myosin heavy chain isoform. The mechanisms underlying the...

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PMID: 11245594
DOI: 10.1152/ajpcell.2001.280.4.c782

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