Article
Mutagenicity of saccharin in a human cell strain.
Mutation research - 1 Jan 2000
Suzuki H, Suzuki N
Abstract excerpt
The mutagenicity of saccharin was investigated by the phenotypic changes of the sensitivity to ouabain lethality in human RSa cells with high susceptibility to UV mutagenicity. At concentrations ranging from 10.0 to 22.5 mg/ml, saccharin induced a dose-dependent increase in the number of mutations to ouabain resistance. This is the first report, to our knowledge, of saccharin having mutagenic activity in human cells.
Topics
- Cell Line
- Cell Survival
- Dose-Response Relationship, Drug
- Humans
- Mutation
- Ouabain
- Saccharin
- Ultraviolet Rays