Article
The genotoxicity of sodium saccharin and sodium chloride in relation to their cancer-promoting properties.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association - 1 Jan 2000
Ashby J
Abstract excerpt
The literature indicates that sodium saccharin is non-reactive to DNA and inactive as a gene mutagen in vitro. At elevated dose levels it is capable of producing structural disturbances in eukaryotic chromosomes in vitro, and it shows intermittent activity as a very weak germ-cell and somatic-cell mutagen in vivo. Its possible mode of action in these respects is speculated on and related to its ability to promote...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.