The genotoxicity of sodium saccharin and sodium chloride in relation to their cancer-promoting properties.

doi:10.1016/0278-6915(85)90145-0

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Article

The genotoxicity of sodium saccharin and sodium chloride in relation to their cancer-promoting properties.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association - 1 Jan 2000

Ashby J

Abstract excerpt

The literature indicates that sodium saccharin is non-reactive to DNA and inactive as a gene mutagen in vitro. At elevated dose levels it is capable of producing structural disturbances in eukaryotic chromosomes in vitro, and it shows intermittent activity as a very weak germ-cell and somatic-cell mutagen in vivo. Its possible mode of action in these respects is speculated on and related to its ability to promote...

Topics

Animals
Cell Transformation, Neoplastic
Chemical Phenomena
Chemistry
Chromosome Aberrations
Dose-Response Relationship, Drug
Female
Humans
In Vitro Techniques
Male
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutagens

Mutation

Rats

Saccharin

Salmonella typhimurium

Sister Chromatid Exchange

Sodium Chloride

Source

Open in PubMed

Identifiers

PMID: 3891557
DOI: 10.1016/0278-6915(85)90145-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-3891557-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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