Article
The impact of polymorphisms in chemokine and chemokine receptors on outcomes in liver transplantation.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons - 1 Aug 2002
Schröppel Bernd, Fischereder Michael, Ashkar Rami, Lin Marvin, Krämer Bernhard K, Mardera Brad, Schiano Tom, Murphy Barbara
Abstract excerpt
Chemokines and their corresponding receptors likely play a central role in directing mononuclear cells to the graft sites during rejection. Genes for the chemokine stromal derived factor-1 (SDF1) and CC chemokine receptors CCR2 and CCR5 are characterized by polymorphisms which alter their function. We genotyped DNA of 207 liver transplant recipients by PCR or PCR-RFLP for CCR2-641, CCR5delta32, and SDF1-3'A...
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