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Article

Methylation profile of the MLH1 promoter region and their relationship to colorectal carcinogenesis.

Genes, chromosomes & cancer - 1 Jan 2003

Miyakura Yasuyuki, Sugano Kokichi, Konishi Fumio, Fukayama Noriko, Igarashi Seiji, Kotake Kenjiro, Matsui Takashi, Koyama Yasuo, Maekawa Masato, Nagai Hideo

Abstract excerpt

Methylation of the MLH1 promoter region has been suggested to be a principal mechanism of gene inactivation in sporadic microsatellite instability (MSI)-positive colorectal carcinoma. Recently, we have shown a novel methylation profile of the MLH1 promoter region (i.e., full, partial, and no methylation), among which full methylation was strongly associated with MSI. In this study, to confirm whether methylation...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12461746
DOI: 10.1002/gcc.10134

Genes

MLH1
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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