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Article

Spatial structure of the dimeric transmembrane domain of the growth factor receptor ErbB2 presumably corresponding to the receptor active state.

The Journal of biological chemistry - 14 Mar 2008

Bocharov Eduard V, Mineev Konstantin S, Volynsky Pavel E, Ermolyuk Yaroslav S, Tkach Elena N, Sobol Alexander G, Chupin Vladimir V, Kirpichnikov Michail P, Efremov Roman G, Arseniev Alexander S

Abstract excerpt

Proper lateral dimerization of the transmembrane domains of receptor tyrosine kinases is required for biochemical signal transduction across the plasma membrane. The spatial structure of the dimeric transmembrane domain of the growth factor receptor ErbB2 embedded into lipid bicelles was obtained by solution NMR, followed by molecular dynamics relaxation in an explicit lipid bilayer. ErbB2 transmembrane segments...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 18178548
DOI: 10.1074/jbc.M709202200

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