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Article

Characterization of the role of EGF-A of low density lipoprotein receptor in PCSK9 binding.

Journal of lipid research - 1 Dec 2013

Gu Hong-mei, Adijiang Ayinuer, Mah Matthew, Zhang Da-wei

Abstract excerpt

Proprotein convertase subtilisin kexin-like 9 (PCSK9) promotes the degradation of low density lipoprotein receptor (LDLR) and plays an important role in regulating plasma LDL-cholesterol levels. We have shown that the epidermal growth factor precursor homology domain A (EGF-A) of the LDLR is critical for PCSK9 binding at the cell surface (pH 7.4). Here, we further characterized the role of EGF-A in binding of...

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Share to Chlorocebus aethiops
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Share to Proprotein Convertase 9

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24103783
DOI: 10.1194/jlr.M041129
PMCID: PMC3826682

Genes

PCSK9
LDLR
EGF
VLDLR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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