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Article

PET imaging of HSV1-tk mutants with acquired specificity toward pyrimidine- and acycloguanosine-based radiotracers.

European journal of nuclear medicine and molecular imaging - 1 Aug 2009

Likar Yury, Dobrenkov Konstantin, Olszewska Malgorzata, Shenker Larissa, Cai Shangde, Hricak Hedvig, Ponomarev Vladimir

Abstract excerpt

PURPOSE: The aim of this study was to create an alternative mutant of the herpes simplex virus type 1 thymidine kinase (HSV1-tk) reporter gene with reduced phosphorylation capacity for acycloguanosine derivatives, but not pyrimidine-based compounds that will allow for successful PET imaging. METH...

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Source

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Identifiers

PMID: 19259663
DOI: 10.1007/s00259-009-1089-x
PMCID: PMC4416642

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19259663-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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