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Article

Acetylation and deacetylation regulate CCAAT/enhancer binding protein beta at K39 in mediating gene transcription.

Molecular and cellular endocrinology - 16 Jul 2008

Ceseña Teresa I, Cui Tracy X, Subramanian Lalitha, Fulton Christina T, Iñiguez-Lluhí Jorge A, Kwok Roland P S, Schwartz Jessica

Abstract excerpt

The transcription factor CCAAT/enhancer binding protein beta (C/EBPbeta) contains multiple acetylation sites, including lysine (K) 39. Mutation of C/EBPbeta at K39, an acetylation site in the transcriptional activation domain, impairs transcription of C/EBPbeta target genes in a dominant-negative fashion. Further, K39 of C/EBPbeta can be deacetylated by HDAC1, and HDAC1 may decrease C/EBPbeta-mediated...

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Identifiers

PMID: 18486321
DOI: 10.1016/j.mce.2008.03.009

Genes

HDAC1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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