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Article

Altered phosphotransfer in an activated mutant of the Saccharomyces cerevisiae two-component osmosensor Sln1p.

Eukaryotic cell - 1 Apr 2002

Ault A D, Fassler J S, Deschenes R J

Abstract excerpt

The SLN1 two-component signaling pathway of Saccharomyces cerevisiae utilizes a multistep phosphorelay mechanism to control osmotic stress responses via the HOG1 mitogen-activated protein kinase pathway and the transcription factor Skn7p. Sln1p consists of a sensor kinase module that undergoes histidine autophosphorylation and a receiver module that autocatalytically transfers the phosphoryl group from histidine...

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Identifiers

PMID: 12455952
DOI: 10.1128/EC.1.2.174-180.2002
PMCID: PMC118030

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Altered phosphotransfer in an activated mutant of the Saccharomyces cerevisiae two-component osmosensor Sln1p.PMID 12455952Read ↗

Phosphorylated Ssk1 prevents unphosphorylated Ssk1 from activating the Ssk2 mitogen-activated protein kinase kinase kinase in the yeast high-osmolarity glycerol osmoregulatory pathway.Semantic proximity Read ↗

Intracellular glycerol levels modulate the activity of Sln1p, a Saccharomyces cerevisiae two-component regulator.Semantic proximity Read ↗

Yeast HOG1 MAP kinase cascade is regulated by a multistep phosphorelay mechanism in the SLN1-YPD1-SSK1 "two-component" osmosensor.Semantic proximity Read ↗

Yeast Skn7p activity is modulated by the Sln1p-Ypd1p osmosensor and contributes to regulation of the HOG pathway.Semantic proximity Read ↗

Ssk1p response regulator binding surface on histidine-containing phosphotransfer protein Ypd1p.Semantic proximity Read ↗

Role for the Ran binding protein, Mog1p, in Saccharomyces cerevisiae SLN1-SKN7 signal transduction.Semantic proximity Read ↗

Analysis of mitogen-activated protein kinase signaling specificity in response to hyperosmotic stress: use of an analog-sensitive HOG1 allele.Semantic proximity Read ↗

Crosstalk between Saccharomycescerevisiae SAPKs Hog1 and Mpk1 is mediated by glycerol accumulation.Semantic proximity Read ↗

A cytoplasmic coiled-coil domain is required for histidine kinase activity of the yeast osmosensor, SLN1.Semantic proximity Read ↗

Activation of the Hog1 MAPK by the Ssk2/Ssk22 MAP3Ks, in the absence of the osmosensors, is not sufficient to trigger osmostress adaptation in Saccharomyces cerevisiae.Semantic proximity Read ↗

Association of the Skn7 and Yap1 transcription factors in the Saccharomyces cerevisiae oxidative stress response.Semantic proximity Read ↗

Structure and function of a transcriptional network activated by the MAPK Hog1.Semantic proximity Read ↗

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