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A quantitative trait locus influencing type 2 diabetes susceptibility maps to a region on 5q in an extended French family.

Diabetes - 1 Dec 2002

Martin Lisa J, Comuzzie Anthony G, Dupont Sophie, Vionnet Nathalie, Dina Christian, Gallina Sophie, Houari Mouna, Blangero John, Froguel Philippe

Abstract excerpt

Type 2 diabetes is a heterogeneous disorder of glucose metabolism characterized by insulin resistance, beta-cell dysfunction, and increased glucose production by the liver. Given the high degree of genetic heterogeneity, multiple genes with small to moderate effects may influence susceptibility to diabetes. To circumvent this limitation, we searched for quantitative trait loci (QTLs) that explain the variation in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12453915
DOI: 10.2337/diabetes.51.12.3568

Genes

CAST
PCSK1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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