Article
Regulation of rho family GTPases is required to prevent axons from crossing the midline.
Developmental biology - 1 Dec 2002
Fritz Janice L, VanBerkum Mark F A
Abstract excerpt
Rho family GTPases are ideal candidates to regulate aspects of cytoskeletal dynamics downstream of axon guidance receptors. To examine the in vivo role of Rho GTPases in midline guidance, dominant negative (dn) and constitutively active (ct) forms of Rho, Drac1, and Dcdc42 are expressed in the Drosophila CNS. When expressed alone, only ctDrac and ctDcdc42 cause axons in the pCC/MP2 pathway to cross the midline...
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