Article
The chemokine receptor CCR5 deletion mutation is associated with MS in HLA-DR4-positive Russians.
Neurology - 26 Nov 2002
Favorova O O, Andreewski T V, Boiko A N, Sudomoina M A, Alekseenkov A D, Kulakova O G, Slanova A V, Gusev E I
Abstract excerpt
The authors studied the possible association between the presence of a 32-base pair deletion allele in CC chemokine receptor 5 gene [3p21] (CCR5 Delta 32 allele) and the occurrence of MS. The presence of CCR5 Delta 32 homozygotes among patients with MS indicates that the absence of CCR5 did not protect against MS. Moreover, the CCR5 Delta 32 mutation was associated with MS in HLA-DR4-positive Russians (p(corr) <...
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