Article
Validation of single nucleotide polymorphism quantification in pooled DNA samples with SNaPIT. A glycosylase-mediated methods for polymorphism detection method.
Molecular biotechnology - 1 Nov 2002
Curran Sarah, Hill Linzy, O'Grady Geraldine, Turic Dragana, Asherson Philip, Taylor Eric, Sham Pak, Craig Ian, Vaughan Pat
Abstract excerpt
Association studies using genome scans to identify quantitative trait loci for multifactorial disorders, with anything approaching reasonable power, have been compromised by the need for a very dense array of genetic markers and large numbers of affected individuals. These requirements impose enormous burdens on the genotyping capacity for most laboratories. DNA pooling has been proposed as a possible approach to...
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