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Article

Loci on chromosomes 14 and 2, distinct from ABCG5/ABCG8, regulate plasma plant sterol levels in a C57BL/6J x CASA/Rk intercross.

Proceedings of the National Academy of Sciences of the United States of America - 10 Dec 2002

Sehayek Ephraim, Duncan Elizabeth M, Lutjohann Dieter, Von Bergmann Klaus, Ono Jennie G, Batta Ashok K, Salen Gerald, Breslow Jan L

Abstract excerpt

Plasma plant sterol levels differ among humans due to genetic and dietary factors. A disease characterized by high plasma plant sterol levels, beta-sitosterolemia, was recently found to be due to mutations at the ABCG5ABCG8 locus. To detect variants at this and other loci, a genetic cross was carried out between two laboratory mouse strains. Parental C57BL6J had almost twice the campesterol and sitosterol levels...

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Identifiers

PMID: 12446833
DOI: 10.1073/pnas.212640599
PMCID: PMC138591

Genes

ABCG5
ABCG8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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