Genetic regulation of serum phytosterol levels and risk of coronary artery disease.

doi:10.1161/CIRCGENETICS.109.907873

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Article

Genetic regulation of serum phytosterol levels and risk of coronary artery disease.

Circulation. Cardiovascular genetics - 1 Aug 2010

Teupser Daniel, Baber Ronny, Ceglarek Uta, Scholz Markus, Illig Thomas, Gieger Christian, Holdt Lesca M, Leichtle Alexander, Greiser Karin H, Huster Dominik, Linsel-Nitschke Patrick, Schäfer Arne, Braund Peter S, Tiret Laurence, Stark Klaus, Raaz-Schrauder Dorette, Fiedler Georg M, Wilfert Wolfgang, Beutner Frank, Gielen Stephan, Grosshennig Anika, König Inke R, Lichtner Peter, Heid Iris M, Kluttig Alexander, El Mokhtari Nour E, Rubin Diana, Ekici Arif B, Reis André, Garlichs Christoph D, Hall Alistair S, Matthes Gert, Wittekind Christian, Hengstenberg Christian, Cambien Francois, Schreiber Stefan, Werdan Karl, Meitinger Thomas, Loeffler Markus, Samani Nilesh J, Erdmann Jeanette, Wichmann H-Erich, Schunkert Heribert, Thiery Joachim

Abstract excerpt

BACKGROUND: Phytosterols are plant-derived sterols that are taken up from food and can serve as biomarkers of cholesterol uptake. Serum levels are under tight genetic control. We used a genomic approach to study the molecular regulation of serum phytosterol levels and potential links to coronary artery disease (CAD). METHODS AND RESULTS: A genome-wide association study for serum phytosterols (campesterol,...

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PMID: 20529992
DOI: 10.1161/CIRCGENETICS.109.907873

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ABCG8
CAD
ABO

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