Article
Role of transcription in plasmid maintenance in the hpr1Delta mutant of Saccharomyces cerevisiae.
Molecular and cellular biology - 1 Dec 2002
Merker Robert J, Klein Hannah L
Abstract excerpt
The Saccharomyces cerevisiae hyperrecombination mutation hpr1Delta results in instability of sequences between direct repeats that is dependent on transcription of the repeat. Here it is shown that the HPR1 gene also functions in plasmid stability in the presence of destabilizing transcription elongation. In the hpr1Delta mutant, plasmid instability results from unchecked transcription elongation, which can be...
Topics
- Adenosine Triphosphatases
- Cell Cycle Proteins
- DEAD-box RNA Helicases
- DNA, Bacterial
- DNA, Fungal
- DNA-Binding Proteins
- Fungal Proteins
- Genes, Fungal
- Mutation
- Nuclear Proteins
- Plasmids