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Activation of the Type I Interferon Pathway Is Enhanced in Response to Human Neuronal Differentiation

7 Mar 2013

Abstract excerpt

Despite the crucial role of innate immunity in preventing or controlling pathogen-induced damage in most, if not all, cell types, very little is known about the activity of this essential defense system in central nervous system neurons, especially in humans. In this report we use both an established neuronal cell line model and an embryonic stem cell-based system to examine human neuronal innate immunity and...

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PMID: 23505563
DOI: 10.1371/journal.pone.0058813

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