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Article

Complementary antioxidant defense by cytoplasmic and mitochondrial peroxiredoxins in Leishmania infantum.

Free radical biology & medicine - 1 Dec 2002

Castro Helena, Sousa Carla, Santos Marta, Cordeiro-da-Silva Anabela, Flohé Leopold, Tomás Ana M

Abstract excerpt

In Kinetoplastida 2-Cys peroxiredoxins are the ultimate members of unique enzymatic cascades for detoxification of peroxides, which are dependent on trypanothione, a small thiol specific to these organisms. Here we report on two distinct Leishmania infantum peroxiredoxins, LicTXNPx and LimTXNPx, that may be involved in such a pathway. LicTXNPx, found in the cytoplasm, is a typical 2-Cys peroxiredoxin encoded by...

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PMID: 12446213
DOI: 10.1016/s0891-5849(02)01089-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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