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Article

Tryparedoxin peroxidase-deficiency commits trypanosomes to ferroptosis-type cell death.

eLife - 26 Jul 2018

Bogacz Marta, Krauth-Siegel R Luise

Abstract excerpt

Tryparedoxin peroxidases, distant relatives of glutathione peroxidase 4 in higher eukaryotes, are responsible for the detoxification of lipid-derived hydroperoxides in African trypanosomes. The lethal phenotype of procyclic Trypanosoma brucei that lack the enzymes fulfils all criteria defining a form of regulated cell death termed ferroptosis. Viability of the parasites is preserved by α-tocopherol,...

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Identifiers

PMID: 30047863
DOI: 10.7554/eLife.37503
PMCID: PMC6117152

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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