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Article

Tryparedoxin peroxidase of Leishmania donovani: molecular cloning, heterologous expression, specificity, and catalytic mechanism.

Archives of biochemistry and biophysics - 15 Jan 2002

Flohé Leopold, Budde Heike, Bruns Karsten, Castro Helena, Clos Joachim, Hofmann Birgit, Kansal-Kalavar Sonia, Krumme Dirk, Menge Ulrich, Plank-Schumacher Karin, Sztajer Helena, Wissing Joseph, Wylegalla Claudia, Hecht Hans-Jürgen

Abstract excerpt

Tryparedoxin peroxidase (TXNPx) of Trypanosomatidae is the terminal peroxidase of a complex redox cascade that detoxifies hydroperoxides by NADPH (Nogoceke et al., Biol. Chem. 378, 827-836, 1997). A gene putatively coding for a peroxiredoxin-type TXNPx was identified in L. donovani and expressed in Escherichia coli to yield an N-terminally His-tagged protein (LdH6TXNPx). LdH6TXNPx proved to be an active...

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PMID: 11795890
DOI: 10.1006/abbi.2001.2688

Genes

TXN
TXN2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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