Article
Activation mechanism of pro-astacin: role of the pro-peptide, tryptic and autoproteolytic cleavage and importance of precise amino-terminal processing.
Journal of molecular biology - 22 Nov 2002
Yiallouros Irene, Kappelhoff Reinhild, Schilling Oliver, Wegmann Frank, Helms Mike W, Auge Astrid, Brachtendorf Gertrud, Berkhoff Eva Grosse, Beermann Bernd, Hinz Hans Jürgen, König Simone, Peter-Katalinic Jasna, Stöcker Walter
Abstract excerpt
Astacin (EC 3.4.24.21) is a prototype for the astacin family and for the metzincin superfamily of zinc peptidases, which comprise membrane-bound and secreted enzymes involved in extracellular proteolysis during tissue development and remodelling. Generally, metzincins are translated as pro-enzymes (zymogens), which are activated by removal of an N-terminal pro-peptide. In astacin, however, the mode of zymogen...
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