Article
Analysis of the premalignant stages of Barrett's oesophagus through to adenocarcinoma by comparative genomic hybridization.
European journal of gastroenterology & hepatology - 1 Nov 2002
Croft Jeanette, Parry Elizabeth M, Jenkins Gareth J, Doak Shareen H, Baxter John N, Griffiths A Paul, Brown Tim H, Parry James M
Abstract excerpt
OBJECTIVES: Barrett's oesophagus is a pre-neoplastic lesion, which develops as a complication of chronic gastro-oesophageal reflux disease and predisposes the patient to oesophageal adenocarcinoma. Our aim was to characterize karyotypic changes that may occur during the progression of Barrett's metaplasia through low-grade dysplasia and high-grade dysplasia to adenocarcinoma. METHODS: The technique of comparative...
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