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Article

Absence of the CAAX endoprotease Rce1: effects on cell growth and transformation.

Molecular and cellular biology - 1 Jan 2002

Bergo Martin O, Ambroziak Patricia, Gregory Cria, George Amanda, Otto James C, Kim Edward, Nagase Hiroki, Casey Patrick J, Balmain Allan, Young Stephen G

Abstract excerpt

After isoprenylation, the Ras proteins and other CAAX proteins undergo two additional enzymatic modifications-endoproteolytic release of the last three amino acids of the protein by the protease Rce1 and methylation of the carboxyl-terminal isoprenylcysteine by the methyltransferase Icmt. This postisoprenylation processing is thought to be important for the association of Ras proteins with membranes. Blocking...

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Share to Alkyl and Aryl Transferases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 11739732
DOI: 10.1128/MCB.22.1.171-181.2002
PMCID: PMC134215

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