Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

C/EBPalpha initiates primitive myelopoiesis in pluripotent embryonic cells.

Blood - 2 Jul 2009

Chen Yaoyao, Costa Ricardo M B, Love Nick R, Soto Ximena, Roth Martin, Paredes Roberto, Amaya Enrique

Abstract excerpt

The molecular mechanisms that underlie the development of primitive myeloid cells in vertebrate embryos are not well understood. Here we characterize the role of cebpa during primitive myeloid cell development in Xenopus. We show that cebpa is one of the first known hematopoietic genes expressed in the embryo. Loss- and gain-of-function studies show that it is both necessary and sufficient for the development of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Pluripotent Stem Cells
Share to Animals, Genetically Modified

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CCAAT-Enhancer-Binding Protein-alpha

Share to Embryonic Stem Cells

Share to Gene Expression Regulation, Developmental

Share to Myelopoiesis

Share to Xenopus

Share to Xenopus laevis

Source

Open in PubMed Open full text

Identifiers

PMID: 19420355
DOI: 10.1182/blood-2008-11-189159
PMCID: PMC3747498

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

C/EBPalpha initiates primitive myelopoiesis in pluripotent embryonic cells.PMID 19420355Read ↗

Cebpα is essential for the embryonic myeloid progenitor and neutrophil maintenance in zebrafish.Semantic proximity Read ↗

c-Myc Is a Critical Target for C/EBPα in GranulopoiesisSemantic proximity Read ↗

Multipotent hematopoietic cell lines derived from C/EBPalpha(-/-) knockout mice display granulocyte macrophage-colony-stimulating factor, granulocyte- colony-stimulating factor, and retinoic acid-induced granulocytic differentiation.Semantic proximity Read ↗

Myeloid lineage switch of Pax5 mutant but not wild-type B cell progenitors by C/EBPalpha and GATA factors.Semantic proximity Read ↗

Dominant-interfering C/EBPalpha stimulates primitive erythropoiesis in zebrafish.Semantic proximity Read ↗

Hoxa9 immortalizes a granulocyte-macrophage colony-stimulating factor-dependent promyelocyte capable of biphenotypic differentiation to neutrophils or macrophages, independent of enforced meis expression.Semantic proximity Read ↗

Human C/EBP-ϵ activator and repressor isoforms differentially reprogram myeloid lineage commitment and differentiationSemantic proximity Read ↗

Impaired granulopoiesis, myelodysplasia, and early lethality in CCAAT/enhancer binding protein ɛ-deficient miceSemantic proximity Read ↗

The +37 kb Cebpa Enhancer Is Critical for Cebpa Myeloid Gene Expression and Contains Functional Sites that Bind SCL, GATA2, C/EBPα, PU.1, and Additional Ets FactorsSemantic proximity Read ↗

A dominant-negative mutant of C/EBPalpha, associated with acute myeloid leukemias, inhibits differentiation of myeloid and erythroid progenitors of man but not mouse.Semantic proximity Read ↗

The Role of C/EBPε in the Terminal Stages of Granulocyte DifferentiationSemantic proximity Read ↗

Identification of a novel enhancer of CEBPE essential for granulocytic differentiationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.