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Article

Rapid estrogen-induced phosphorylation of the SRC-3 coactivator occurs in an extranuclear complex containing estrogen receptor.

Molecular and cellular biology - 1 Sept 2005

Zheng Fuzhong F, Wu Ray-Chang, Smith Carolyn L, O'Malley Bert W

Abstract excerpt

SRC-3/AIB1/ACTR/pCIP/RAC3/TRAM1 is a primary transcriptional coregulator for estrogen receptor (ER). Six SRC-3 phosphorylation sites have been identified, and these can be induced by steroids, cytokines, and growth factors, involving multiple kinase signaling pathways. Using phosphospecific antibodies for six phosphorylation sites, we investigated the mechanisms involved in estradiol (E2)-induced SRC-3...

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Source

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Identifiers

PMID: 16135815
DOI: 10.1128/MCB.25.18.8273-8284.2005
PMCID: PMC1234335

Genes

SRC
RAC3
TRAM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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