Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Diurnal variation in PAI-1 activity predominantly confined to the 4G-allele of the PAI-1 gene.

Thrombosis and haemostasis - 1 Nov 2002

Hoekstra Tiny, Geleijnse Johanna M, Schouten Evert G, Kluft Cornelis

Abstract excerpt

We examined the diurnal pattern in Plasminogen Activator Inhibitor-type 1 (PAI-1) activity and Plasminogen activator (t-PA) in relation to the 4G/5G-polymorphism in the promoter of the PAI-1 gene. The analyses were performed in the Arnhem Elderly Study, a population-based study of 598 elderly. A single blood sample was drawn and the time of blood sampling was recorded (between 8 a.m. and 5.30 p.m.). Plasma PAI-1...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged, 80 and over
Share to Circadian Rhythm
Share to Cohort Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Frequency

Share to Plasminogen Activator Inhibitor 1

Share to Polymorphism, Genetic

Share to Promoter Regions, Genetic

Share to Tissue Plasminogen Activator

Source

Identifiers

PMID: 12428096

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Diurnal variation in PAI-1 activity predominantly confined to the 4G-allele of the PAI-1 gene.PMID 12428096Read ↗

The 4G5G polymorphism in the gene for PAI-1 and the circadian oscillation of plasma PAI-1.Semantic proximity Read ↗

Myocardial infarction occurs with a similar 24 h pattern in the 4G/5G versions of plasminogen activator inhibitor-1.Semantic proximity Read ↗

Circadian clock genes cause activation of the human PAI-1 gene promoter with 4G/5G allelic preference.Semantic proximity Read ↗

4G/4G genotype of PAI-1 gene is associated with reduced risk of stroke in elderly.Semantic proximity Read ↗

Genetics of Plasminogen Activator Inhibitor-1 (PAI-1) in a Ghanaian Population.Semantic proximity Read ↗

4G/5G plasminogen activator inhibitor-1 polymorphisms and haplotypes are associated with pneumonia.Semantic proximity Read ↗

Allele-specific increase in basal transcription of the plasminogen-activator inhibitor 1 gene is associated with myocardial infarction.Semantic proximity Read ↗

The plasminogen activator inhibitor 1 4G/5G polymorphism is not associated with longevity: a study in octogenarians.Semantic proximity Read ↗

The PAI-1 Gene Locus 4G/5G Polymorphism Is Associated With a Family History of Coronary Artery DiseaseSemantic proximity Read ↗

Regular exercise, plasminogen activator inhibitor-1 (PAI-1) activity and the 4G/5G promoter polymorphism in the PAI-1 gene.Semantic proximity Read ↗

Plasminogen activator inhibitor-1 4G/5G promoter polymorphism and PAI-1 plasma levels in young patients with ischemic stroke.Semantic proximity Read ↗

Plasminogen activator inhibitor-1 (PAI-1) promoter 4G/5G genotype and increased PAI-1 circulating levels in postmenopausal women with coronary artery disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.