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Article

The 4G5G polymorphism in the gene for PAI-1 and the circadian oscillation of plasma PAI-1.

Blood - 1 Mar 2003

van der Bom Johanna G, Bots Michiel L, Haverkate Frits, Kluft Cornelis, Grobbee Diederick E

Abstract excerpt

Plasminogen activator inhibitor type I (PAI-1) antigen concentrations follow a circadian oscillation peaking in the morning. Some individuals show no apparent circadian rhythm, while others show up to a 10-fold variation in PAI-1 over 24 hours. Results from experimental studies suggest that a polymorphism in the promoter of the gene for PAI-1 (4G5G) directly influences the circadian expression of the PAI-1 gene....

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Identifiers

PMID: 12406875
DOI: 10.1182/blood-2002-07-2181

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The 4G5G polymorphism in the gene for PAI-1 and the circadian oscillation of plasma PAI-1.PMID 12406875Read ↗

Diurnal variation in PAI-1 activity predominantly confined to the 4G-allele of the PAI-1 gene.Semantic proximity Read ↗

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4G/5G plasminogen activator inhibitor-1 polymorphisms and haplotypes are associated with pneumonia.Semantic proximity Read ↗

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Interactive effect of PAI-1 4G/5G genotype and salt intake on PAI-1 antigen.Semantic proximity Read ↗

Comprehensive survey of common genetic variation at the plasminogen activator inhibitor-1 locus and relations to circulating plasminogen activator inhibitor-1 levels.Semantic proximity Read ↗

Plasminogen activator inhibitor type-1 (PAI-1) polymorphism 4G/5G is associated with prostate cancer among men with a positive family history.Semantic proximity Read ↗

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