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Article

Circadian clock genes cause activation of the human PAI-1 gene promoter with 4G/5G allelic preference.

FEBS letters - 7 Aug 2006

Chong Nelson W, Codd Veryan, Chan Danny, Samani Nilesh J

Abstract excerpt

Increased plasminogen activator inhibitor-1 (PAI-1) activity is associated with greater risk of myocardial infarction. PAI-1 expression is regulated by a 4G/5G promoter polymorphism. The 4G allele is associated with higher PAI-levels and greater circadian variation. Here we show that clock protein heterodimers BMAL/CLOCK cause greater activation (approximately 2-fold, P<0.05) of the 4G allele. Site-directed...

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Source

Identifiers

PMID: 16857194
DOI: 10.1016/j.febslet.2006.07.014

Genes

CLOCK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Circadian clock genes cause activation of the human PAI-1 gene promoter with 4G/5G allelic preference.PMID 16857194Read ↗

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