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Article

Identification of two tRNA thiolation genes required for cell growth at extremely high temperatures.

The Journal of biological chemistry - 19 May 2006

Shigi Naoki, Sakaguchi Yuriko, Suzuki Tsutomu, Watanabe Kimitsuna

Abstract excerpt

Thermostability of tRNA in thermophilic bacteria is effected by post-transcriptional modifications, such as 2-thioribothymidine (s2T) at position 54. Using a proteomics approach, we identified two genes (ttuA and ttuB; tRNA-two-thiouridine) that are essential for the synthesis of s2T in Thermus thermophilus. Mutation of either gene completely abolishes thio-modification of s2T, and these mutants exhibit a...

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PMID: 16547008
DOI: 10.1074/jbc.M511675200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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