Article
Polymorphism of alpha-adducin in Japanese patients with essential hypertension.
Hypertension research : official journal of the Japanese Society of Hypertension - 1 Mar 1998
Tamaki S, Iwai N, Tsujita Y, Nakamura Y, Kinoshita M
Abstract excerpt
Recently, a molecular variant of alpha-adducin (with tryptophan instead of glycine at amino acid number 460) has been reported to be more common among Italian and French hypertensive individuals than among controls. Moreover, hypertensive individuals with Trp460 exhibit a greater sensitivity to changes in sodium balance and a greater fall in blood pressure in response to diuretic treatment. In the present study,...
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