Article
The beta 5' loop of the pancreatic lipase C2-like domain plays a critical role in the lipase-lipid interactions.
Biochemistry - 19 Nov 2002
Chahinian Henri, Bezzine Sofiane, Ferrato Francine, Ivanova Margarita G, Perez Barbara, Lowe Mark E, Carrière Frédéric
Abstract excerpt
The structural similarities between the C-terminal domain of human pancreatic lipase (C-HPL) and C2 domains suggested a similar function, the interaction with lipids. The catalytic N-terminal domain (N-HPL) and C-HPL were produced as individual proteins, and their partitioning between the water phase and the triglyceride-water interface was assessed using trioctanoin emulsions (TC8). N-HPL did not bind...
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