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Article

Aromatic residues in the C terminus of apolipoprotein C-III mediate lipid binding and LPL inhibition.

Journal of lipid research - 1 May 2017

Meyers Nathan L, Larsson Mikael, Vorrsjö Evelina, Olivecrona Gunilla, Small Donald M

Abstract excerpt

Plasma apoC-III levels correlate with triglyceride (TG) levels and are a strong predictor of CVD outcomes. ApoC-III elevates TG in part by inhibiting LPL. ApoC-III likely inhibits LPL by competing for lipid binding. To probe this, we used oil-drop tensiometry to characterize binding of six apoC-III variants to lipid/water interfaces. This technique monitors the dependence of lipid binding on surface pressure,...

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Adsorption
Amino Acid Sequence
Apolipoprotein C-II
Lipid Metabolism
Lipoprotein Lipase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Structure-Activity Relationship

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Identifiers

PMID: 28159869
DOI: 10.1194/jlr.M071126
PMCID: PMC5408602

Genes

LPL

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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