Article
Lipoprotein lipase domain function.
The Journal of biological chemistry - 8 Apr 1994
Wong H, Davis R C, Thuren T, Goers J W, Nikazy J, Waite M, Schotz M C
Abstract excerpt
Human lipoprotein lipase (LPL) monomer consists of two domains, a larger NH2-terminal domain that contains catalytic residues and a smaller COOH-terminal domain that modulates substrate specificity and is a major determinant of heparin binding. Analyses of NH2-terminal domain function were perfor...
Topics
- Animals
- Binding Sites
- Cattle
- Cells, Cultured
- DNA, Complementary
- Heparin
- Humans
- Lipoprotein Lipase
- Mutation
- Serine
- Substrate Specificity