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Article

The complete influenza hemagglutinin fusion domain adopts a tight helical hairpin arrangement at the lipid:water interface.

Proceedings of the National Academy of Sciences of the United States of America - 22 Jun 2010

Lorieau Justin L, Louis John M, Bax Ad

Abstract excerpt

All but five of the N-terminal 23 residues of the HA2 domain of the influenza virus glycoprotein hemagglutinin (HA) are strictly conserved across all 16 serotypes of HA genes. The structure and function of this HA2 fusion peptide (HAfp) continues to be the focus of extensive biophysical, computational, and functional analysis, but most of these analyses are of peptides that do not include the strictly conserved...

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Identifiers

PMID: 20534508
DOI: 10.1073/pnas.1006142107
PMCID: PMC2895095

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