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Article

MDR1 pharmacogenetics: frequency of the C3435T mutation in exon 26 is significantly influenced by ethnicity.

Pharmacogenetics - 1 Apr 2001

Ameyaw M M, Regateiro F, Li T, Liu X, Tariq M, Mobarek A, Thornton N, Folayan G O, Githang'a J, Indalo A, Ofori-Adjei D, Price-Evans D A, McLeod H L

Abstract excerpt

P-glycoprotein (PGP), the product of the multidrug resistance gene (MDR1), acts as an energy-dependent efflux pump that exports its substrates out of the cell. PGP expression is an important factor regulating absorption of a wide variety of medications. It has also been associated with intrinsic and acquired cross resistance to a number of structurally unrelated anticancer drugs. A single nucleotide polymorphism...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11337937
DOI: 10.1097/00008571-200104000-00005

Genes

PGP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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