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Article

Val64Ile polymorphism in the C-C chemokine receptor 2 is associated with reduced coronary artery calcification.

Arteriosclerosis, thrombosis, and vascular biology - 1 Nov 2002

Valdes Ana M, Wolfe Megan L, O'Brien Eamonn J, Spurr Nigel K, Gefter Warren, Rut Andrew, Groot Pieter H E, Rader Daniel J

Abstract excerpt

OBJECTIVE: Studies in mice have shown that genetic disruption of monocyte chemotactic protein-1 or its receptor, the C-C chemokine receptor 2 (CCR2), inhibits atherosclerosis, but few data exist in humans to suggest that the monocyte chemotactic protein-1-CCR2 interaction is important in atherogenesis. A common polymorphism in the human CCR2 gene resulting in a substitution of isoleucine for valine (Val64Ile) has...

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Source

Identifiers

PMID: 12426226
DOI: 10.1161/01.atv.0000038486.48400.e7

Genes

CCR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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