Article
Interleukin-12 gene polymorphisim in patients with giant cell arteritis, polymyalgia rheumatica and elderly-onset rheumatoid arthritis.
Clinical and experimental rheumatology - 1 Jan 2000
Alvarez-Rodriguez L, Martínez-Taboada V M, López-Hoyos M, Mata C, Fernandez Prieto L, Agudo-Bilbao M, Calvo J, Ruiz Soto M, Rodriguez-Valverde V, Ruiz T, Blanco R, Corrales A, Carrasco-Marín E
Abstract excerpt
OBJECTIVE: The cytokine profile suggests that giant cell arteritis (GCA) is a Th1-driven disease, in which local IFN-gamma plays a critical role in the development of a systemic arteritis. IL-12 is a potent inducer of IFN-gamma and is critically involved in biasing an immune response towards a Th...
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