Article

Extracellular phosphate impairs the albumin-producing phenotype of HepaRG cells with HNF4A downregulation and ERK activation: potential implications for chronic kidney disease-associated hypoalbuminemia

2026-05-28

Abstract excerpt

<title>Abstract</title> <p>Background Hyperphosphatemia is a common complication of chronic kidney disease (CKD) and has been implicated in systemic inflammation, protein-energy wasting, anemia, and skeletal muscle wasting. Hypoalbuminemia is also frequent in CKD and is associated with poor clinical outcomes. Although CKD-associated hypoalbuminemia is generally interpreted in the context of malnutrition, inflamm...

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Literature Corpus work: 55976c63-e4d2-5aa8-a854-b6835d397b25
DOI: 10.21203/rs.3.rs-9675073/v1

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Extracellular phosphate impairs the albumin-producing phenotype of HepaRG cells with HNF4A downregulation and ERK activation: potential implications for chronic kidney disease-associated hypoalbuminemiaDOI 10.21203/rs.3.rs-9675073/v1Read

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