Inflammatory leiomyosarcoma shows frequent co-expression of smooth and skeletal muscle markers supporting a primitive myogenic phenotype: a report of 9 cases with a proposal for reclassification as low-grade inflammatory myogenic tumor.

doi:10.1007/s00428-020-02774-z

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Inflammatory leiomyosarcoma shows frequent co-expression of smooth and skeletal muscle markers supporting a primitive myogenic phenotype: a report of 9 cases with a proposal for reclassification as low-grade inflammatory myogenic tumor.

Virchows Archiv : an international journal of pathology - 1 Aug 2020

Michal Michael, Rubin Brian P, Kazakov Dmitry V, Michalová Květoslava, Šteiner Petr, Grossmann Petr, Hájková Veronika, Martínek Petr, Švajdler Marian, Agaimy Abbas, Hadravský Ladislav, Kalmykova Antonina V, Konishi Eiichi, Heidenreich Filip, Michal Michal

Abstract excerpt

Inflammatory leiomyosarcoma (ILMS) is a very rare soft tissue tumor that usually follows an indolent clinical course, but long-term follow-up studies are lacking. Recent publications primarily focused on its genetic profile characterized by a near haploid genome. One study also showed these tumors to have upregulation of genes known to be crucial for skeletal muscle differentiation. Nevertheless,...

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PMID: 32078043
DOI: 10.1007/s00428-020-02774-z

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