Bovine IgM antibodies with exceptionally long complementarity‐determining region 3 of the heavy chain share unique structural properties conferring restricted VH + Vλ pairings

Abstract excerpt

Naturally occurring antibody repertoires of cattle (Bos taurus) include a group of IgMlambda antibodies with exceptionally long complementarity-determining region 3 of the heavy chain (CDR3H) segments, containing multiple Cys residues. These massive CDR3H segments will greatly influence the tertiary and quaternary structures of the bovine IgM combining sites. As an antibody's combining site is formed by both...

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